pleioh2g (version 0.1.0)

pleiotropyh2_nocor_computing_single: Compute pleioh2g before bias correction for target disease

Description

This function is used to compute pleioh2g after bias correction for target disease

Usage

pleiotropyh2_nocor_computing_single(
  G,
  phenotype,
  h2_vector,
  h2_vector_mat,
  Results_full_rg,
  Results_full_rg_array
)

Value

A `list` containing the following elements: - `target_disease` (character): The value "401.1". - `target_disease_h2_est` (numeric): target disease h2g. - `target_disease_h2_se` (numeric): target disease h2g_se. - `selected_auxD` (character): auxiliary diseases. - `h2pleio_uncorr` (numeric): pre-correction pleiotropic heritability estimate. - `h2pleio_uncorr_se` (numeric): pre-correction pleiotropic heritability jackknife s.e. estimate. - `percentage_h2pleio_uncorr` (numeric): pre-correction percentage of pleiotropic heritability estimate. - `percentage_h2pleio_uncorr_se` (numeric): pre-correction percentage of pleiotropic heritability jackknife s.e. estimate. - `percentage_h2pleio_jackknife_uncorr` (numeric): vector of all pre-correction percentage of pleiotropic heritability jackknife estimates.

Arguments

G

index of target disease.

phenotype

Vector of the phenotype name

h2_vector

h2g vector for all traits - aligned as the order in phenotype file

h2_vector_mat

h2g array from jackknife-block estimates for all traits - aligned as the order in phenotype file

Results_full_rg

genetic correlation matrix.- aligned as the order in phenotype file

Results_full_rg_array

genetic correlation jackknife-block array.- aligned as the order in phenotype file

Examples

G <- 1
data(Results_full_rg_15D)
data(Results_full_rg_array_15D)
data(h2_vector_15D)
data(h2_vector_mat_15D)
phenotype<-c("401.1","244.5","318","735.3","411.4",
"427.2","454.1","278.1","250.2","550.1","530.11",
"296.22","519.8","562.1","763")
h2pleiobeforecorr<-pleiotropyh2_nocor_computing_single(G,phenotype,h2_vector_15D,
h2_vector_mat_15D,Results_full_rg_15D,Results_full_rg_array_15D)