read_m

`read_m()` Read M from either internal or external file

Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.

Yujie Zhao

pleioh2g

Estimation of Pleiotropic Heritability from Genome-Wide
Association Studies (GWAS) Summary Statistics

read_m function

<dl><dt>ld</dt>
<dd>(character) Path to directory containing ld score files, ending in `*.l2.ldscore.gz`. Default is `NA`, which will utilize the built-in ld score files from Pan-UK Biobank for the ancestry specified in `ancestry`.</dd></dl>

Arguments

Read M from either internal or external file - refer to ldscr R package (https://github.com/mglev1n/ldscr) — read_m

<dl>

<dt>ld</dt>
<dd>(character) Path to directory containing ld score files, ending in `*.l2.ldscore.gz`. Default is `NA`, which will utilize the built-in ld score files from Pan-UK Biobank for the ancestry specified in `ancestry`.</dd>

</dl>

read_m: Read M from either internal or external file - refer to ldscr R package (https://github.com/mglev1n/ldscr)

Description

Usage

Value

Arguments