h2_liability

`h2_liability()` converts heritability estimates from the observed to liability scale.

Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.

Yujie Zhao

pleioh2g

Estimation of Pleiotropic Heritability from Genome-Wide
Association Studies (GWAS) Summary Statistics

h2_liability function

<dl><dt>h2</dt>
<dd>(numeric) Estimate of observed-scale heritability</dd>
<dt>sample_prev</dt>
<dd>(numeric) Proportion of cases in the current sample</dd>
<dt>population_prev</dt>
<dd>(numeric) Population prevalence of trait</dd></dl>

Arguments

Convert Heritability to Liability Scale — h2_liability

<dl>

<dt>h2</dt>
<dd>(numeric) Estimate of observed-scale heritability</dd>


<dt>sample_prev</dt>
<dd>(numeric) Proportion of cases in the current sample</dd>


<dt>population_prev</dt>
<dd>(numeric) Population prevalence of trait</dd>

</dl>

h2_liability: Convert Heritability to Liability Scale

Description

Usage

Value

Arguments

Examples