enzymes

Liver enzyme data collected from 218 patients with liver disease (Plomteux, 1980). The laboratory profile consists of enzymatic activity measured for four liver enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH) and ornithine carbamyltransferase (OCT).

datasets

Extends the approach proposed by Firth (1993) for bias
reduction of MLEs in exponential family models to the
multinomial logistic regression model with general covariate
types.  Modification of the logistic regression score function
to remove first-order bias is equivalent to penalizing the
likelihood by the Jeffreys prior, and yields penalized maximum
likelihood estimates (PLEs) that always exist.  Hypothesis
testing is conducted via likelihood ratio statistics.  Profile
confidence intervals (CI) are constructed for the PLEs.

Sarah Colby

pmlr

Penalized Multinomial Logistic Regression

enzymes function

A data frame with 218 rows and the following 6 columns:
  <dl>
    <dt><code>Patient</code></dt><dd>Patient ID</dd> <dt><code>Group</code></dt><dd>Four diagnostic groups were considered: acute viral hepatitis (1), persistent chronic hepatitis (2), aggressive chronic hepatitis (3) and post-necrotic cirrhosis (4).</dd> <dt><code>AST</code></dt><dd>Aspartate aminotransferase (U/L)</dd> <dt><code>ALT</code></dt><dd>Alanine aminotransferase (U/L)</dd> <dt><code>GLDH</code></dt><dd>Glutamate dehydrogenase (U/L</dd> <dt><code>OCT</code></dt><dd>Ornithine carbamyltransferase (U/L)</dd> </dl> 

Format

Albert, A. and Harris, E. K. (1984) <em>Multivariate Interpretation of Clinical Laboratory Data</em>. Dekker: New York, Chapter 5, Appendix I.

enzymes: Liver Enzyme Data

Description

Usage

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References