model_parm_updater_mlx

Update a Monolix model input to define non-NN and NN parameters as model inputs

internal

An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.

Dominic Bräm

pmxNODE

Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'

Bernhard Steiert

Gilbert Koch

Matthew Fidler

model_parm_updater_mlx function

<dl><dt>text</dt>
<dd>(list of strings) The Monolix model with each line as element of a list</dd>
<dt>model_parm_names</dt>
<dd>(list of strings) A list of all non-NN parameters</dd>
<dt>nn_thetas</dt>
<dd>(list of strings) A list of all NN parameters</dd></dl>

Arguments

Author

Internal: Update input line — model_parm_updater_mlx

<dl>

<dt>text</dt>
<dd>(list of strings) The Monolix model with each line as element of a list</dd>


<dt>model_parm_names</dt>
<dd>(list of strings) A list of all non-NN parameters</dd>


<dt>nn_thetas</dt>
<dd>(list of strings) A list of all NN parameters</dd>

</dl>

model_parm_updater_mlx: Internal: Update input line

Description

Usage

Value

Arguments

Author