pre_fixef_extractor_nm

Function to extract THETA estimates from a results file of an already run NONMEM file.

An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.

Dominic Bräm

pmxNODE

Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'

Bernhard Steiert

Gilbert Koch

Matthew Fidler

pre_fixef_extractor_nm function

<dl><dt>res_path</dt>
<dd>(string) (Path/)Name of the results file of a NONMEM run, must include file extension, e.g., &#8220;.res&#8221;</dd></dl>

Arguments

Author

THETA extraction from results file — pre_fixef_extractor_nm

<dl>

<dt>res_path</dt>
<dd>(string) (Path/)Name of the results file of a NONMEM run, must include file extension, e.g., &#8220;.res&#8221;</dd>

</dl>

pre_fixef_extractor_nm: THETA extraction from results file

Description

Usage

Value

Arguments

Author

Details

Examples