pmxTools (version 1.3)

calc_ss_1cmt: Calculate C(t) for a 1-compartment linear model at steady-state

Description

Calculate C(t) for a 1-compartment linear model at steady-state

Usage

calc_ss_1cmt(tad, tau, dose, dur = NULL, tinf = NULL, ...)
calc_ss_1cmt_linear_bolus(tad, tau, dose, ...)
calc_ss_1cmt_linear_infusion(tad, tau, dose, tinf, ...)
calc_ss_1cmt_linear_oral_0(tad, tau, dose, dur, ...)
calc_ss_1cmt_linear_oral_0_lag(tad, tau, dose, dur, ...)
calc_ss_1cmt_linear_oral_1_lag(tad, tau, dose, ...)
calc_ss_1cmt_linear_oral_1(tad, tau, dose, ...)

Value

Concentration of drug at requested time (t) after a single dose, given provided set of parameters and variables.

Arguments

tad

Time after dose (h)

tau

Dosing interval (h)

dose

Dose

dur

Duration of zero-order absorption (h)

tinf

Duration of infusion (h)

...

Passed to `calc_derived_1cpt()`

Functions

• calc_ss_1cmt_linear_bolus(): Calculate C(t) for a 1-compartment linear model with IV bolus dosing at steady state

• calc_ss_1cmt_linear_infusion(): Calculate C(t) for a 1-compartment linear model with infusion at steady state

• calc_ss_1cmt_linear_oral_0(): Calculate C(t) for a 1-compartment linear model with zero-order oral absorption at steady state

• calc_ss_1cmt_linear_oral_0_lag(): Calculate C(t) for a 1-compartment linear model with zero-order oral absorption at steady state, with lag time

• calc_ss_1cmt_linear_oral_1_lag(): Calculate C(t) for a 1-compartment linear model with first-order oral absorption at steady state, with lag time

• calc_ss_1cmt_linear_oral_1(): Calculate C(t) for a 1-compartment linear model with first-order oral absorption at steady state

Author

Justin Wilkins,

Bill Denney,

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Examples

Ct <- calc_ss_1cmt_linear_bolus(t=0:24, CL=6, V=25, dose=600, tau=24)
Ct <- calc_ss_1cmt_linear_infusion(tad=0:36, CL=2, V=25, dose=600, tinf=1, tau=24)
Ct <- calc_ss_1cmt_linear_oral_0(tad=0:36, CL=2, V=25, dose=600, dur=1, tau=24)
Ct <- calc_ss_1cmt_linear_oral_0_lag(tad=0:36, CL=2, V=25, dose=600, dur=1, tau=24, tlag=1.5)
Ct <- calc_ss_1cmt_linear_oral_1_lag(tad=0:36, CL=2, V=25, dose=600,
    ka=0.25, tlag=0.75, tau=24)
Ct <- calc_ss_1cmt_linear_oral_1(tad=0:36, CL=2, V=25, dose=600, ka=0.25, tau=24)