pmxTools (version 1.3)

sample_sigma: Sample from the multivariate normal distribution using the SIGMA variance-covariance matrix to generate new sets of simulated EPSILONs from NONMEM output.

Description

Sample from the multivariate normal distribution using the SIGMA variance-covariance matrix to generate new sets of simulated EPSILONs from NONMEM output.

Usage

sample_sigma(nmRun, n, seed)

Value

A data frame containing n samples from the multivariate normal distribution, using the estimated NONMEM SIGMA variance-covariance matrix. This provides n sets of EPSILON estimates suitable for simulation of new datasets.

Arguments

nmRun

Root filename for the NONMEM run (e.g. "run315").

n

Number of samples required.

seed

Random seed.

Author

Justin Wilkins,

See Also

NONMEM (https://www.iconplc.com/innovation/nonmem/)

Examples

if (FALSE) {
 sigDist <- sample_sigma("run315", 5000, seed=740727)
}