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polyPK (version 3.1.0)

The Pharmacokinetics (PK) of Multi-Component Drugs Using a Metabolomics Approach

Description

Poly-PK strategy is a new strategy of pharmacokinetic analysis of multi-component drugs (Guoxiang Xie, Tianlu Chen, Wei Jia, et al. (2012); Ke Lan, Guoxiang Xie and Wei Jia. (2013)). This package is the first implementation of the Poly-PK strategy with 10 easy-to-use functions.

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Version

Install

install.packages('polyPK')

Monthly Downloads

4

Version

3.1.0

License

GPL-2

Maintainer

Tianlu Chen

Last Published

July 11th, 2018

Functions in polyPK (3.1.0)

Get the secondary metabolites of the absorbed drug constitutes

Plot the correlation diagram of two datasets

Calculate the representative pharmacokinetics parameters and plot the time-intensity curves of specified compounds.

Get the same compounds in two datasets

Test data of study design

Plot the PCA or PLSDA score figures and trajectories on input data

Test data of absorbed drug metabolites

Plot the heatmap of input data

Test data of differential metabolites

Test data of endogenous metabolites

The drug constitutes dataset (data frame)

The post-dose metabolites dataset (data frame)

Get the differential compounds across all the time points

The pre-dose metabolites dataset (data frame)

Preprocess the input data

Test data of same compounds.

Get the altered endogenous metabolites from the differential compounds

Get the absorbed drug constitutes from the differential compounds