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poolVIM (version 1.0.0)

Gene-Based Association Tests using the Actual Impurity Reduction (AIR) Variable Importance

Description

Gene-based association tests using the actual impurity reduction (AIR) variable importance. The function aggregates AIR importance measures from a group of SNPs or probes and outputs a p-value for each gene. The procedures builds upon the method described in and will be published soon.

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Version

Install

install.packages('poolVIM')

Monthly Downloads

146

Version

1.0.0

License

GPL (>= 2)

Maintainer

Stefano Nembrini

Last Published

July 30th, 2018

Functions in poolVIM (1.0.0)

gaussianize null variable importances

after the Actual Impurity Reduction Importance is computed with a Random Forest, pvalues from different probes or SNPs belonging to the same gene can be aggregated in order to obtain a single pvalue for that gene. Correlation between probes can also be taken into account.