KEGGSim: KEGG Semantic Similarity Between two Genes
Description
Given two genes, this function will calculate the KEGG semantic similarity between them, based on the shared pathways between the genes.
Usage
KEGGSim(protein1, protein2)
Arguments
protein1
Entrez gene id.
protein2
Another entrez gene id.
Value
The KEGG semantic similarity, using the Jaccard index.
References
[1] M. Kanehisa and S. Goto, "KEGG: Kyoto Encyclopedia of Genes and Genomes", Nucleic Acids Research, vol. 28, no. 1, pp. 27 -30, 2000.
[2] P. Jaccard, "Etude comparative de la distribution florale dans une portion des Alpes et des Jura", Bull. Soc. Vaud. Sci. Nat, vol. 37, p. 541, 1901.