Learn R Programming

⚠️There's a newer version (0.2.6) of this package.Take me there.

precautionary (version 0.1-4)

Safety Diagnostics for Dose-Escalation Trial Designs

Description

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020), "Retrospective analysis of a fatal dose-finding trial" .

Copy Link

Version

Install

install.packages('precautionary')

Monthly Downloads

36

Version

0.1-4

License

MIT + file LICENSE

Maintainer

David C. Norris

Last Published

September 21st, 2020

Functions in precautionary (0.1-4)

precautionary-package

Safety Diagnostics for Dose-Escalation Trial Designs

plot,mtdi_generator-method

Visualize n samples from an mtdi_generator object

Extend an existing simulation, using one of several stopping criteria

format.safetytab

Format a phase 1 trial safety tabulation to show significant digits only

hyper_mtdi_lognormal-class

Hyperprior for lognormal MTDi distributions

as.data.table.precautionary

Convert an object of class c('precautionary','simulations') to a data.table

Override escalation:::phase1_sim to incorporate latent toxicity tolerances

test_draw_samples

Test performance of draw_samples function

print.precautionary

Specialize print method for objects of class simulations

Specialize print method defined for class simulations

plot,mtdi_distribution-method

Visualize an mtdi_distribution object

simulate_trials

Simulate trials defined via package escalation

Output a kable for a simulation summary of class safetytab

simulation_function.u_i

Get a function that simulates dose-escalation trials using latent u_i

summary.precautionary

Specialize a method defined in package 'escalation' for class 'simulations'

mtdi_lognormal-class

A lognormal MTDi distribution

Override cohorts_of_n to include latent toxicity tolerances