The coverage histogram is based on a single-cell whole-genome
sequencing (scWGS) data through MALBAK protocol. The accession number of the
raw data is SRR1301329. Five million reads are randomly sampled from the raw
data to generate this coverage histogram.
Arguments
Details
A two-column matrix.
The first column is the frequency \(j = 1,2,\dots\); and the second column
is \(N_j\), the number of nucleotides in the genome covered exactly
\(j\) times.
References
Zong, C., Lu, S., Chapman, A. R., & Xie, X. S. (2012). Genome-wide detection
of single-nucleotide and copy-number variations of a single human cell.
Science, 338(6114), 1622-1626.