The protr package is a comprehensive toolkit for generating various numerical representation schemes of protein sequence. The descriptors are extensively utilized in bioinformatics and chemogenomics research. The commonly used descriptors include amino acid composition, autocorrelation, CTD, conjoint traid, quasi-sequence order, pseudo amino acid composition, and profile-based descriptors derived by Position-Specific Scoring Matrix (PSSM). The descriptors for proteochemometric (PCM) modeling include the scales-based descriptors derived by principal components analysis, factor analysis, multidimensional scaling, amino acid properties (AAindex), 20+ classes of 2D and 3D molecular descriptors (Topological, WHIM, VHSE, etc.), and BLOSUM/PAM matrix-derived descriptors. The protr package also integrates the function of parallelized similarity computation derived by pairwise protein sequence alignment and Gene Ontology (GO) semantic similarity measures.
| Package: | protr |
| Type: | Package |
| License: | BSD_3_clause |
Xiao, N., Cao, D.-S., Zhu, M.-F., and Xu, Q.-S. (2015). protr/ProtrWeb: R package and web server for generating various numerical representation schemes of protein sequences. Bioinformatics 31 (11), 1857--1859.