SimCovariates-class

.sim_covariates

A class for specifying covariate distributions and covariance for
simulation studies.

Bayesian dynamic borrowing is an approach to incorporating external
data to supplement a randomized, controlled trial analysis in which
external data are incorporated in a dynamic way (e.g., based on similarity
of outcomes); see Viele 2013 <doi:10.1002/pst.1589> for an overview.
This package implements the hierarchical commensurate prior approach to dynamic borrowing
as described in Hobbes 2011 <doi:10.1111/j.1541-0420.2011.01564.x>.
There are three main functionalities. First, 'psborrow2' provides a user-friendly
interface for applying dynamic borrowing on the study results handles the Markov Chain
Monte Carlo sampling on behalf of the user. Second, 'psborrow2' provides a
simulation framework to compare different borrowing parameters (e.g. full borrowing, no
borrowing, dynamic borrowing) and other trial and borrowing characteristics
(e.g. sample size, covariates) in a unified way. Third, 'psborrow2' provides
a set of functions to generate data for simulation studies, and also allows
the user to specify their own data generation process. This package is designed to
use the sampling functions from 'cmdstanr' which can be installed from
<https://stan-dev.r-universe.dev>.

Matt Secrest

psborrow2

Bayesian Dynamic Borrowing Analysis and Simulation

Isaac Gravestock

Craig Gower-Page

Manoj Khanal

Mingyang Shan

Kexin Jin

Zhi Yang

Genentech, Inc. 

SimCovariates-class function

<dl>
<dt><code>covariates</code></dt>
<dd>list. List of covariate mean values or probabilities as
generated through <code>bin_var()</code> (class <code>SimVarBin</code> or <code>cont_var()</code>
(class <code>SimVarCont</code>).</dd></dl>
<dt><code>covariance_internal</code></dt>
<dd>matrix. Covariance matrix before binarization
for internal patients.</dd>
<dt><code>covariance_external</code></dt>
<dd>matrix. Covariance matrix before binarization
for external patients.</dd>

Slots

SimCovariates Class — SimCovariates-class

<dl>
<dt><code>covariates</code></dt>
<dd>list. List of covariate mean values or probabilities as
generated through <code>bin_var()</code> (class <code>SimVarBin</code> or <code>cont_var()</code>
(class <code>SimVarCont</code>).</dd>


<dt><code>covariance_internal</code></dt>
<dd>matrix. Covariance matrix before binarization
for internal patients.</dd>


<dt><code>covariance_external</code></dt>
<dd>matrix. Covariance matrix before binarization
for external patients.</dd>


</dl>

<code>SimCovariates</code> Class

SimCovariates-class: `SimCovariates` Class

Description

Arguments

Slots