mammaca

Data of a study among women with breast cancer

datasets

Pooling, backward and forward selection of linear, logistic and Cox regression models in
multiply imputed datasets. Backward and forward selection can be done
from the pooled model using Rubin's Rules (RR), the D1, D2, D3, D4 and
the median p-values method. This is also possible for Mixed models.
The models can contain continuous, dichotomous, categorical and restricted
cubic spline predictors and interaction terms between	all these type of predictors.
The stability of the models	can be evaluated using (cluster) bootstrapping. The package
further contains functions to pool model performance measures as ROC/AUC, Reclassification,
R-squared, scaled Brier score, H&L test and calibration	plots for logistic regression models.
Internal validation can be done across multiply imputed datasets with cross-validation or
bootstrapping. The adjusted intercept after shrinkage of pooled regression coefficients
can be obtained. Backward and forward selection as part of internal validation is possible.
A function to externally validate logistic prediction models in multiple imputed
datasets is available and a function to compare models. For Cox models a strata variable
can be included.
Eekhout (2017) <doi:10.1186/s12874-017-0404-7>.
Wiel (2009) <doi:10.1093/biostatistics/kxp011>.
Marshall (2009) <doi:10.1186/1471-2288-9-57>.

Martijn Heymans

psfmi

Prediction Model Pooling, Selection and Performance Evaluation
Across Multiply Imputed Datasets

Iris Eekhout

mammaca function

A data frame with 1207 observations on the following 10 variables.<dl>
 <dt><code>id</code></dt>
<dd>continuous</dd> <dt><code>time</code></dt>
<dd>continuous, Time (months)</dd> <dt><code>status</code></dt>
<dd>dichotomous: 1=yes, 0=no</dd> <dt><code>er</code></dt>
<dd>Estrogen Receptor Status, 1=positive, 0=negative</dd> <dt><code>age</code></dt>
<dd>continuous</dd> <dt><code>histgrad</code></dt>
<dd>categorical</dd> <dt><code>ln_yesno</code></dt>
<dd>lymph nodes, 0=no, 1=yes</dd> <dt><code>pathsd</code></dt>
<dd>dichotomous: Pathological Tumor Size</dd> <dt><code>pr</code></dt>
<dd>dichotomous: Progesterone Receptor Status, 0=negative, 1=positive</dd> 
</dl>

Format

Data of a study among women with breast cancer — mammaca

A data frame with 1207 observations on the following 10 variables.<dl>
 <dt><code>id</code></dt>
<dd>continuous</dd>

 <dt><code>time</code></dt>
<dd>continuous, Time (months)</dd>

 <dt><code>status</code></dt>
<dd>dichotomous: 1=yes, 0=no</dd>

 <dt><code>er</code></dt>
<dd>Estrogen Receptor Status, 1=positive, 0=negative</dd>

 <dt><code>age</code></dt>
<dd>continuous</dd>

 <dt><code>histgrad</code></dt>
<dd>categorical</dd>

 <dt><code>ln_yesno</code></dt>
<dd>lymph nodes, 0=no, 1=yes</dd>

 <dt><code>pathsd</code></dt>
<dd>dichotomous: Pathological Tumor Size</dd>

 <dt><code>pr</code></dt>
<dd>dichotomous: Progesterone Receptor Status, 0=negative, 1=positive</dd>

 
</dl>

mammaca: Data of a study among women with breast cancer

Description

Usage

Arguments

Format

Examples