psrwe_survkm

Estimate the mean of a survival outcome at a given time point based on
PS-integrated Kaplan-Meier approach. Variance can be estimated by the
Jackknife methods. Apply to the case when there is only one external
data source.

High-quality real-world data can be transformed into scientific
real-world evidence for regulatory and healthcare decision-making
using proven analytical methods and techniques. For example, propensity
score (PS) methodology can be applied to select a subset of real-world
data containing patients that are similar to those in the current clinical
study in terms of baseline covariates, and to stratify the selected
patients together with those in the current study into more homogeneous
strata. Then, statistical methods such as the power prior approach or
composite likelihood approach can be applied in each stratum to draw
inference for the parameters of interest. This package provides
functions that implement the PS-integrated real-world
evidence analysis methods such as
Wang et al. (2019) <doi:10.1080/10543406.2019.1657133>,
Wang et al. (2020) <doi:10.1080/10543406.2019.1684309>, and
Chen et al. (2020) <doi:10.1080/10543406.2020.1730877>.

Wei-Chen Chen

psrwe

PS-Integrated Methods for Incorporating Real-World Evidence in
Clinical Studies

Chenguang Wang

Trustees of Columbia University 

psrwe_survkm function

<dl><dt>dta_psbor</dt>
<dd>A class <code>PSRWE_BOR</code> object generated by
<code>psrwe_borrow</code>.</dd>
<dt>pred_tp</dt>
<dd>A numeric value corresponding to the time of interest
(e.g., 365 days or 1 year)</dd>
<dt>v_time</dt>
<dd>Column name corresponding to event time</dd>
<dt>v_event</dt>
<dd>Column name corresponding to event status</dd>
<dt>stderr_method</dt>
<dd>Method for computing StdErr, see Details</dd>
<dt>n_bootstrap</dt>
<dd>Number of bootstrap samples (for bootstrap stderr)</dd>
<dt>...</dt>
<dd>Additional Parameters</dd></dl>

Arguments

PS-Integrated Kaplan-Meier Estimation — psrwe_survkm

<dl>

<dt>dta_psbor</dt>
<dd>A class <code>PSRWE_BOR</code> object generated by
<code>psrwe_borrow</code>.</dd>


<dt>pred_tp</dt>
<dd>A numeric value corresponding to the time of interest
(e.g., 365 days or 1 year)</dd>


<dt>v_time</dt>
<dd>Column name corresponding to event time</dd>


<dt>v_event</dt>
<dd>Column name corresponding to event status</dd>


<dt>stderr_method</dt>
<dd>Method for computing StdErr, see Details</dd>


<dt>n_bootstrap</dt>
<dd>Number of bootstrap samples (for bootstrap stderr)</dd>


<dt>...</dt>
<dd>Additional Parameters</dd>

</dl>

psrwe_survkm: PS-Integrated Kaplan-Meier Estimation

Description

Usage

Value

Arguments

Details

Examples