rwe_km

Estimate survival probability based on Kaplan-Meier estimator for a single PS
stratum

High-quality real-world data can be transformed into scientific
real-world evidence for regulatory and healthcare decision-making
using proven analytical methods and techniques. For example, propensity
score (PS) methodology can be applied to select a subset of real-world
data containing patients that are similar to those in the current clinical
study in terms of baseline covariates, and to stratify the selected
patients together with those in the current study into more homogeneous
strata. Then, statistical methods such as the power prior approach or
composite likelihood approach can be applied in each stratum to draw
inference for the parameters of interest. This package provides
functions that implement the PS-integrated real-world
evidence analysis methods such as
Wang et al. (2019) <doi:10.1080/10543406.2019.1657133>,
Wang et al. (2020) <doi:10.1080/10543406.2019.1684309>, and
Chen et al. (2020) <doi:10.1080/10543406.2020.1730877>.

Wei-Chen Chen

psrwe

PS-Integrated Methods for Incorporating Real-World Evidence in
Clinical Studies

Chenguang Wang

Trustees of Columbia University 

rwe_km function

<dl><dt>dta_cur</dt>
<dd>Matrix of time and event from a PS stratum in the current
study</dd>
<dt>dta_ext</dt>
<dd>Matrix of time and event from a PS stratum in the external
data source</dd>
<dt>n_borrow</dt>
<dd>Number of subjects to be borrowed</dd>
<dt>pred_tps</dt>
<dd>Time points to be estimated (unique and sorted)</dd>
<dt>stderr_method</dt>
<dd>Method for computing StdErr (available for naive only)</dd></dl>

Arguments

Kaplan-Meier Estimation — rwe_km

<dl>

<dt>dta_cur</dt>
<dd>Matrix of time and event from a PS stratum in the current
study</dd>


<dt>dta_ext</dt>
<dd>Matrix of time and event from a PS stratum in the external
data source</dd>


<dt>n_borrow</dt>
<dd>Number of subjects to be borrowed</dd>


<dt>pred_tps</dt>
<dd>Time points to be estimated (unique and sorted)</dd>


<dt>stderr_method</dt>
<dd>Method for computing StdErr (available for naive only)</dd>

</dl>

rwe_km: Kaplan-Meier Estimation

Description

Usage

Value

Arguments