rwe_lrk

Estimate log-rank estimates for a single PS
stratum

High-quality real-world data can be transformed into scientific
real-world evidence for regulatory and healthcare decision-making
using proven analytical methods and techniques. For example, propensity
score (PS) methodology can be applied to select a subset of real-world
data containing patients that are similar to those in the current clinical
study in terms of baseline covariates, and to stratify the selected
patients together with those in the current study into more homogeneous
strata. Then, statistical methods such as the power prior approach or
composite likelihood approach can be applied in each stratum to draw
inference for the parameters of interest. This package provides
functions that implement the PS-integrated real-world
evidence analysis methods such as
Wang et al. (2019) <doi:10.1080/10543406.2019.1657133>,
Wang et al. (2020) <doi:10.1080/10543406.2019.1684309>, and
Chen et al. (2020) <doi:10.1080/10543406.2020.1730877>.

Wei-Chen Chen

psrwe

PS-Integrated Methods for Incorporating Real-World Evidence in
Clinical Studies

Chenguang Wang

Trustees of Columbia University 

rwe_lrk function

<dl><dt>dta_cur</dt>
<dd>Matrix of time and event from a PS stratum in the current
study (control arm only)</dd>
<dt>dta_ext</dt>
<dd>Matrix of time and event from a PS stratum in the external
data source (control arm only)</dd>
<dt>dta_cur_trt</dt>
<dd>Matrix of time and event from a PS stratum in current
study (treatment arm only)</dd>
<dt>n_borrow</dt>
<dd>Number of subjects to be borrowed</dd>
<dt>pred_tps</dt>
<dd>All time points of events (unique and sorted)</dd>
<dt>stderr_method</dt>
<dd>Method for computing StdErr (available for naive only)</dd></dl>

Arguments

Log-rank Estimation — rwe_lrk

<dl>

<dt>dta_cur</dt>
<dd>Matrix of time and event from a PS stratum in the current
study (control arm only)</dd>


<dt>dta_ext</dt>
<dd>Matrix of time and event from a PS stratum in the external
data source (control arm only)</dd>


<dt>dta_cur_trt</dt>
<dd>Matrix of time and event from a PS stratum in current
study (treatment arm only)</dd>


<dt>n_borrow</dt>
<dd>Number of subjects to be borrowed</dd>


<dt>pred_tps</dt>
<dd>All time points of events (unique and sorted)</dd>


<dt>stderr_method</dt>
<dd>Method for computing StdErr (available for naive only)</dd>

</dl>

rwe_lrk: Log-rank Estimation

Description

Usage

Value

Arguments