randomizeR (version 1.4.2)

abcdRand: Sampling algorithm for abcd

Description

Sampling algorithm for abcd

Usage

abcdRand(N, a, K = 2)

Arguments

N

integer for the total sample size of the trial.

a

nonnegative parameter which my be adjusted according to how strongly it is desired to balance the experiment. a = 0 gives the complete randomization, while the assignments become more deterministic as a increases.

K

number of treatment groups (e.g. K=2 if we compare one experimental against one control treatment).

Value

A vector with the allocation sequence for a clinical trial. It will contain a zero (resp. 1) at position i, when patient i is allocated to treatment A (resp. B).

References

A. B. Antognini and A. Giovagnoli (2004) A new 'biased coin design' for the sequential allocation of two treatments. Journal of the Royal Statistical Society. Series C (Applied Statistics) 53, No. 4, 651-664