Representing Chen's Design
chenRand(N, mti, p, K = 2)
integer for the total sample size of the trial.
maximum tolerated imbalance in patient numbers during the trial.
success probability of the biased coin (e.g. in Efron's Biased Coin Design).
number of treatment groups (e.g. K=2 if we compare one experimental against one control treatment).
A vector with the allocation sequence for a clinical trial.
It will contain a zero (resp. 1) at position i
, when patient i
is allocated to treatment A (resp. B).
Chen Yung-Pin (1999) Biased coin design with imbalance tolerance. Comm. in Stat., 15, 953-975.