rashnu (version 0.1.2)

rashnuBasic: Interactive Sample Size Calculator for Survival Studies (Shiny App)

Description

Launches a Shiny web application that calculates required sample sizes and expected event numbers for different types of survival analysis designs:

• Two-group Non-Inferiority

• Two-group Superiority (Lakatos method)

• One-sample survival test (with transformation methods)

Usage

rashnuBasic()

Value

Launches a Shiny app in the default browser.

Details

Users can specify survival probabilities, accrual and follow-up durations, allocation ratios, non-inferiority margins, transformation methods, and test types. The app dynamically adjusts input UI based on the selected design and displays results in a data table format.

Test Types:

• "ni" - Non-Inferiority (two-group exponential survival comparison)

• "sup" - Superiority (Lakatos method with logrank/Gehan/Tarone-Ware weighting)

• "one" - One-sample survival test with multiple transformation options

Included References:

• Jung SH, Chow SC. Journal of Biopharmaceutical Statistics, 2012.

• Lakatos E. Biometrics, 1988.

• Lakatos & Lan. Statistics in Medicine, 1992.

• Fleming & Harrington. Counting Processes and Survival Analysis, 1991.

• Borgan 0, Andersen PK et al. Springer-Verlag, 1993.

• Nagashima et al. Pharmaceutical Statistics, 2020.

Examples

if (interactive()) {
  rashnuBasic()
}