elNetMolDataNCI60: NCI60 Molecular Data
Description
Z-scores of values for a variety of assays conducted on the NCI-60 to facilitate comparison.
Z-scores calculated over the 60 cell lines for the given feature.Details
A list containing various assay values:
{ Copy number values; Described in Pubmed ID: 24670534 }
- exp
{ Expression values; Obtained from "RNA: 5 Platform Gene Transcript"
http://discover.nci.nih.gov/cellminer/loadDownload.do; Missing values
imputed using the R package "impute" }
- mut
{ Mutation values; Deleterious mutations obtained from TODO }
- mir
{ MicroRNA values; Obtained from "RNA: Agilent Human microRNA (V2)"
http://discover.nci.nih.gov/cellminer/loadDownload.do }
- pro
{ Reverse protein lysate array values; Obtain from "Protein: Lysate Array"
http://discover.nci.nih.gov/cellminer/loadDownload.do }
- mda
{ NCI-60 metadata.
{Proportion of genome copy number gains; Described in Pubmed ID: 24670534}
- CNV_LOSS
{Proportion of genome copy number losses; Described in Pubmed ID: 24670534}
- CNV_TOTAL
{Sum of CNV_GAIN and CNV_LOSS}
- P53_BIN
{Binary TP53 profile curated by William Reinhold }
- MSI_OGAN_BIN
{Binary microsatellite instability (MSI) profile curated by Ogan Abaan using COSMIC data; Obtained from Supplementary Table 1 - Ogan Whole Exome Sequencing (WES) paper in Cancer Res. }
- EPITHELIAL
{Epithelial by tissue of origin - pattern extracted from the CellMiner cell line metadata http://discover.nci.nih.gov/cellminer/celllineMetadata.do }
- EPITHELIAL_KURT
{Kurt Kohn curation for epithelial-like cell lines based on molecular parameters described in Pubmed ID: 24940735}
- DELETERIOUS
{Total deleterious variants from WES dataset; Fabricio Sousa curation}
- MISSENSE
{Total missense variants from WES dataset; Fabricio Sousa curation}
- SILENT
{Total silent variants from WES dataset; Fabricio Sousa curation}
- TOTAL_AA
{Total amino acid changing variants from WES dataset; Fabricio Sousa curation}
- CELL-CELL
{Cell-to-cell adhesion curated by William Reinhold }
- DOUBLINGTIME
{The doubling time pattern was extracted from the CellMiner cell line metadata
http://discover.nci.nih.gov/cellminer/celllineMetadata.do }
}References
http://discover.nci.nih.gov/cellminer