getMedSenLineActivity

a character vector specifying identifier(s) for compound(s) of interest.

idSet

the minimum activity z-score for a sensitive cell line (default=0.5).

senLineActZThreshold

a logical value indicating whether to base results strictly on
experimental data included in CellMiner (default=TRUE).

onlyCellMinerExps

character string indicating data source (default="NCI60").
Currently only "NCI60" is supported.

dataSource

Returns a vector of median sensitive cell line activity (-logGI50) values
for a set of compounds.

The NCI-60 cancer cell line panel has been used over the course of
  several decades as an anti-cancer drug screen. This panel was developed as
  part of the Developmental Therapeutics Program (DTP, http://dtp.nci.nih.gov/)
  of the U.S. National Cancer Institute (NCI). Thousands of compounds have been
  tested on the NCI-60, which have been extensively characterized by many
  platforms for gene and protein expression, copy number, mutation, and others
  (Reinhold, et al., 2012). The purpose of the CellMiner project
  (http://discover.nci.nih.gov/cellminer) has been to integrate data
  from multiple platforms used to analyze the NCI-60 and to provide a powerful
  suite of tools for exploration of NCI-60 data.

getMedSenLineActivity: Returns a vector of median sensitive cell line activity (-logGI50) values for a set of compounds.

Description

Usage

Arguments

Value

concept

Examples