cdfTruncatedBoxCox

Function to calculate the RI from a set of parameters

Indirect method for the estimation of reference intervals (RIs)
using Real-World Data ('RWD') and methods for comparing and verifying RIs.
Estimates RIs by applying advanced statistical methods to routine
diagnostic test measurements, which include both pathological and
non-pathological samples, to model the distribution of non-pathological
samples. This distribution is then used to derive reference intervals
and support RI verification, i.e., deciding if a specific RI is suitable
for the local population. The package also provides functions for
printing and plotting algorithm results. See ?refineR for a detailed
description of features. Version 1.0 of the algorithm is described in
'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional
guidance is in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>. The
verification method is described in 'Beck et al. (2025)'
<doi:10.1515/cclm-2025-0728>.

Matthias Beck

refineR

Reference Interval Estimation using Real-World Data

Tatjana Ammer

Christopher M Rank

Andre Schuetzenmeister

cdfTruncatedBoxCox function

<dl><dt>mu</dt>
<dd>(numeric) mean of the distribution</dd>
<dt>sigma</dt>
<dd>(numeric) standard deviation of the distribution</dd>
<dt>lambda</dt>
<dd>(numeric) Box-Cox transformation parameter</dd>
<dt>shift</dt>
<dd>(numeric) shift of the distribution</dd>
<dt>RIperc</dt>
<dd>(numeric) vector of percentiles for which the reference interval should be calculated</dd></dl>

Arguments

Matthias Beck <a href="/link/matthias.beck.mb1%40roche.com?package=refineR&version=2.0.0" data-mini-rdoc="refineR::matthias.beck.mb1@roche.com">matthias.beck.mb1@roche.com</a>, Christopher Rank <a href="/link/christopher.rank%40roche.com?package=refineR&version=2.0.0" data-mini-rdoc="refineR::christopher.rank@roche.com">christopher.rank@roche.com</a>, Tatjana Ammer <a href="/link/tatjana.ammer%40roche.com?package=refineR&version=2.0.0" data-mini-rdoc="refineR::tatjana.ammer@roche.com">tatjana.ammer@roche.com</a>

Author

Function to calculate the RI from a set of parameters — cdfTruncatedBoxCox

<dl>

<dt>mu</dt>
<dd>(numeric) mean of the distribution</dd>


<dt>sigma</dt>
<dd>(numeric) standard deviation of the distribution</dd>


<dt>lambda</dt>
<dd>(numeric) Box-Cox transformation parameter</dd>


<dt>shift</dt>
<dd>(numeric) shift of the distribution</dd>


<dt>RIperc</dt>
<dd>(numeric) vector of percentiles for which the reference interval should be calculated</dd>

</dl>

Matthias Beck <a href='mailto:matthias.beck.mb1@roche.com'>matthias.beck.mb1@roche.com</a>, Christopher Rank <a href='mailto:christopher.rank@roche.com'>christopher.rank@roche.com</a>, Tatjana Ammer <a href='mailto:tatjana.ammer@roche.com'>tatjana.ammer@roche.com</a>

cdfTruncatedBoxCox: Function to calculate the RI from a set of parameters

Description

Usage

Value

Arguments

Author

References