defineSearchRegions

The function estimates the start search regions for mu and sigma for each lambda. Further it determines an appropriate
region around the main peak 'ab' that is used for all lambdas.

Indirect method for the estimation of reference intervals (RIs)
using Real-World Data ('RWD') and methods for comparing and verifying RIs.
Estimates RIs by applying advanced statistical methods to routine
diagnostic test measurements, which include both pathological and
non-pathological samples, to model the distribution of non-pathological
samples. This distribution is then used to derive reference intervals
and support RI verification, i.e., deciding if a specific RI is suitable
for the local population. The package also provides functions for
printing and plotting algorithm results. See ?refineR for a detailed
description of features. Version 1.0 of the algorithm is described in
'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional
guidance is in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>. The
verification method is described in 'Beck et al. (2025)'
<doi:10.1515/cclm-2025-0728>.

Matthias Beck

refineR

Reference Interval Estimation using Real-World Data

Tatjana Ammer

Christopher M Rank

Andre Schuetzenmeister

defineSearchRegions function

<dl><dt>x</dt>
<dd>(numeric) values specifying data points comprising pathological
and non-pathological values</dd>
<dt>lambdaVec</dt>
<dd>(numeric) transformation parameter for inverse Box-Cox transformation</dd>
<dt>roundingBase</dt>
<dd>(numeric) describing the rounding base of the dataset</dd>
<dt>abEst</dt>
<dd>(numeric) vector with already estimated abSearchReg and abHist for second definition of search regions</dd></dl>

Arguments

Tatjana Ammer <a href="/link/tatjana.ammer%40roche.com?package=refineR&version=2.0.0" data-mini-rdoc="refineR::tatjana.ammer@roche.com">tatjana.ammer@roche.com</a>

Author

Helper function to define search regions for mu and sigma and to get the region around the main peak 'ab' — defineSearchRegions

<dl>

<dt>x</dt>
<dd>(numeric) values specifying data points comprising pathological
and non-pathological values</dd>


<dt>lambdaVec</dt>
<dd>(numeric) transformation parameter for inverse Box-Cox transformation</dd>


<dt>roundingBase</dt>
<dd>(numeric) describing the rounding base of the dataset</dd>


<dt>abEst</dt>
<dd>(numeric) vector with already estimated abSearchReg and abHist for second definition of search regions</dd>

</dl>

Tatjana Ammer <a href='mailto:tatjana.ammer@roche.com'>tatjana.ammer@roche.com</a>

defineSearchRegions: Helper function to define search regions for mu and sigma and to get the region around the main peak 'ab'

Description

Usage

Value

Arguments

Author