getVerificationArgs

This function adapts the list of test arguments based on the margin type and additional test parameters

Indirect method for the estimation of reference intervals (RIs)
using Real-World Data ('RWD') and methods for comparing and verifying RIs.
Estimates RIs by applying advanced statistical methods to routine
diagnostic test measurements, which include both pathological and
non-pathological samples, to model the distribution of non-pathological
samples. This distribution is then used to derive reference intervals
and support RI verification, i.e., deciding if a specific RI is suitable
for the local population. The package also provides functions for
printing and plotting algorithm results. See ?refineR for a detailed
description of features. Version 1.0 of the algorithm is described in
'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional
guidance is in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>. The
verification method is described in 'Beck et al. (2025)'
<doi:10.1515/cclm-2025-0728>.

Matthias Beck

refineR

Reference Interval Estimation using Real-World Data

Tatjana Ammer

Christopher M Rank

Andre Schuetzenmeister

getVerificationArgs function

<dl><dt>RIdata</dt>
<dd>specifying the RI of the local population: (1) (object) of class RWDRI or (2) (numeric) representation of reference limits</dd>
<dt>RIcand</dt>
<dd>specifying the RI that needs to be verified: (1) (object) of class RWDRI or (2) (numeric) representation of reference limits</dd>
<dt>RIperc</dt>
<dd>(numeric) value specifying the percentiles, which define the reference interval (default c(0.025, 0.975))</dd>
<dt>pointEst</dt>
<dd>(character) specifying the point estimate determination: (1) using the full dataset ("fullDataEst"),
(2) calculating the median model from the bootstrap samples ("medianBS"), (2) works only if NBootstrap &gt; 0</dd>
<dt>verbose</dt>
<dd>(logical) specifying if additional warning messages are printed</dd></dl>

Arguments

Matthias Beck <a href="/link/matthias.beck.mb1%40roche.com?package=refineR&version=2.0.0" data-mini-rdoc="refineR::matthias.beck.mb1@roche.com">matthias.beck.mb1@roche.com</a>

Author

Get the correct values for RI, RIperc, Lambda, and Shift for the verification — getVerificationArgs

<dl>

<dt>RIdata</dt>
<dd>specifying the RI of the local population: (1) (object) of class RWDRI or (2) (numeric) representation of reference limits</dd>


<dt>RIcand</dt>
<dd>specifying the RI that needs to be verified: (1) (object) of class RWDRI or (2) (numeric) representation of reference limits</dd>


<dt>RIperc</dt>
<dd>(numeric) value specifying the percentiles, which define the reference interval (default c(0.025, 0.975))</dd>


<dt>pointEst</dt>
<dd>(character) specifying the point estimate determination: (1) using the full dataset ("fullDataEst"),
(2) calculating the median model from the bootstrap samples ("medianBS"), (2) works only if NBootstrap &gt; 0</dd>


<dt>verbose</dt>
<dd>(logical) specifying if additional warning messages are printed</dd>

</dl>

Matthias Beck <a href='mailto:matthias.beck.mb1@roche.com'>matthias.beck.mb1@roche.com</a>

getVerificationArgs: Get the correct values for RI, RIperc, Lambda, and Shift for the verification

Description

Usage

Value

Arguments

Author