conf_int95

Calculates 95 percent confidence intervals for the lower and upper reference limits obtained with the reflim algorithm.

Uses an indirect method based on truncated quantile-quantile plots to estimate reference limits from routine laboratory data. The principle of the method was developed by Robert G Hoffmann (1963) <doi:10.1001/jama.1963.03060110068020> and modified by Georg Hoffmann and colleagues (2015) <doi:10.1515/labmed-2015-0104>, (2020) <doi:10.1515/labmed-2020-0005>, and (2022) <doi:10.1007/978-3-031-15509-3_31>.

Georg Hoffmann

reflimR

Reference Limit Estimation Using Routine Laboratory Data

Sandra Klawitter

Frank Klawonn

conf_int95 function

<dl> <dt>n</dt>
<dd>number of observations</dd> <dt>lower.limit</dt>
<dd>positive number indicating the lower limit of the reference interval</dd> <dt>upper.limit</dt>
<dd>positive number indicating the upper limit of the reference interval</dd> <dt>lognormal</dt>
<dd>Boolean indicating whether a lognormal distribution should be assumed</dd> <dt>apply.rounding</dt>
<dd>Boolean indicating whether the confidence limits should be rounded</dd></dl>

Arguments

Confidence intervals of estimated reference limits — conf_int95

<dl>

 <dt>n</dt>
<dd>number of observations</dd>

 <dt>lower.limit</dt>
<dd>positive number indicating the lower limit of the reference interval</dd>

 <dt>upper.limit</dt>
<dd>positive number indicating the upper limit of the reference interval</dd>

 <dt>lognormal</dt>
<dd>Boolean indicating whether a lognormal distribution should be assumed</dd>

 <dt>apply.rounding</dt>
<dd>Boolean indicating whether the confidence limits should be rounded</dd>

</dl>

conf_int95: Confidence intervals of estimated reference limits

Description

Usage

Value

Arguments

Details

Examples