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rld (version 1.0)

Analyze and Design Repeated Low-Dose Challenge Experiments

Description

Analyzes data from repeated low-dose challenge experiments and provide vaccine efficacy estimates. In addition, this package can provide guidance to design repeated low-dose challenge studies.

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Version

Install

install.packages('rld')

Monthly Downloads

8

Version

1.0

License

GPL (>= 2)

Maintainer

Bin Yao

Last Published

January 12th, 2017

Functions in rld (1.0)

rld-package

Designing and Analyzing Repeated Low-Dose Challenge Experiments
SampleData

Simulated Sample Data for Illustration
calcVEk

Calculate Per-Challenge Vaccine Efficacy
transdata

Transfer Input Data Frame to Model Fitting Data Frame
rld.design

Power analysis for the Repeated-Low Dose Experiments
rld

Fit a Discrete-Time Survival Model
rld.fit

Discrete-Time Survival Model Fitting Function
lrtest

Likelihood Ratio Test
calcVEt

Calculate Vaccine Efficacy Before or At the Time of Challenge t
calcpk

Calculate Per-Challenge Probability of Infection