rmstcompsens (version 0.1.5)

rmstcompsens-package: Comparing restricted mean survival time when survival curves have divergent tails

Description

Performs two-sample comparisons using the restricted mean survival time (RMST) when survival curves end at different time points between groups. This package implements a sensitivity approach that allows the threshold timepoint tau to be specified after the longest survival time in the shorter survival group. Two kinds of between-group contrast estimators (the difference in RMST and the ratio of RMST) are computed.

Author

Kentaro Ueno

Maintainer: Kentaro Ueno <[e-mail]>

References

Uno H, Claggett B, Tian L, Inoue E, Gallo P, Miyata T, Schrag D, Takeuchi M, Uyama Y, Zhao L, Skali H, Solomon S, Jacobus S, Hughes M, Packer M, Wei LJ. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. Journal of clinical Oncology 2014, 32, 2380-2385.

Hajime Uno, Lu Tian, Miki Horiguchi, Angel Cronin, Chakib Battioui and James Bell (2020). survRM2: Comparing Restricted Mean Survival Time. R package version 1.0-3. https://CRAN.R-project.org/package=survRM2

Ueno K, Morita S. Sensitivity Analysis for Restricted Mean Survival Time When Survival Curves Have Divergent Tails. Ther Innov Regul Sci (2023).

See Also

survival survRM2

Examples

#--- sample data ---#
time  <- c(0.7,1.6,3.1,4.5,7.6,11,13.5,18.6,22.7,26.5,0.4,2.2,2.9,3.8,5.2,8.6,9.8,10.1,13.3,14.9)
event <- c(0,1,1,0,0,1,0,1,0,0,0,1,0,1,0,1,0,1,1,0)
arm   <- c(1,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0)
data <- data.frame(time,event,arm)
#--- analysis ---#
library(rmstcompsens)
a = diftimermst(data,24)
print(a)