param_calcSubjectsFunction

<p>Optionally, a function can be entered that defines the way of performing the sample size
recalculation. By default, sample size recalculation is performed with conditional power with specified
<code>minNumberOfSubjectsPerStage</code> and <code>maxNumberOfSubjectsPerStage</code> (see details and examples).</p>

calcSubjectsFunction

<p>Parameter Description: Calculate Subjects Function</p>

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

param_calcSubjectsFunction: Parameter Description: Calculate Subjects Function

Description

Arguments