param_adaptations

<p>A vector of length <code>kMax - 1</code> indicating whether or not an adaptation takes 
place at interim k, default is <code>rep(TRUE, kMax - 1)</code>.</p>

adaptations

<p>Parameter Description: Adaptations</p>

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

param_adaptations: Parameter Description: Adaptations

Description

Arguments