param_directionUpper

<p>Specifies the direction of the alternative, 
only applicable for one-sided testing; default is <code>TRUE</code>
which means that larger values of the test statistics yield smaller p-values.</p>

directionUpper

<p>Parameter Description: Direction Upper</p>

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

param_directionUpper: Parameter Description: Direction Upper

Description

Arguments