param_bindingFutility

If <code>bindingFutility = TRUE</code> is specified the calculation of 
the critical values is affected by the futility bounds and the futility threshold is binding in the 
sense that the study must be stopped if the futility condition was reached (default is <code>FALSE</code>).

bindingFutility

Parameter Description: Binding Futility

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

param_bindingFutility function

<dl><dt>bindingFutility</dt>
<dd>If <code>bindingFutility = TRUE</code> is specified the calculation of 
the critical values is affected by the futility bounds and the futility threshold is binding in the 
sense that the study must be stopped if the futility condition was reached (default is <code>FALSE</code>).</dd></dl>

Arguments

Parameter Description: Binding Futility — param_bindingFutility

<dl>

<dt>bindingFutility</dt>
<dd>If <code>bindingFutility = TRUE</code> is specified the calculation of 
the critical values is affected by the futility bounds and the futility threshold is binding in the 
sense that the study must be stopped if the futility condition was reached (default is <code>FALSE</code>).</dd>

</dl>