param_maxNumberOfSubjectsPerStage

When performing a data driven sample size recalculation, 
the vector <code>maxNumberOfSubjectsPerStage</code> with length kMax determines the maximum number 
of subjects per stage (i.e., not cumulated), the first element is not taken into account.
For two treatment arms, it is the number of subjects for both treatment arms. 
For multi-arm designs <code>maxNumberOfSubjectsPerStage</code> refers
to the maximum number of subjects per selected active arm.

maxNumberOfSubjectsPerStage

Parameter Description: Maximum Number Of Subjects Per Stage

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

param_maxNumberOfSubjectsPerStage function

<dl><dt>maxNumberOfSubjectsPerStage</dt>
<dd>When performing a data driven sample size recalculation, 
the vector <code>maxNumberOfSubjectsPerStage</code> with length kMax determines the maximum number 
of subjects per stage (i.e., not cumulated), the first element is not taken into account.
For two treatment arms, it is the number of subjects for both treatment arms. 
For multi-arm designs <code>maxNumberOfSubjectsPerStage</code> refers
to the maximum number of subjects per selected active arm.</dd></dl>

Arguments

Parameter Description: Maximum Number Of Subjects Per Stage — param_maxNumberOfSubjectsPerStage

<dl>

<dt>maxNumberOfSubjectsPerStage</dt>
<dd>When performing a data driven sample size recalculation, 
the vector <code>maxNumberOfSubjectsPerStage</code> with length kMax determines the maximum number 
of subjects per stage (i.e., not cumulated), the first element is not taken into account.
For two treatment arms, it is the number of subjects for both treatment arms. 
For multi-arm designs <code>maxNumberOfSubjectsPerStage</code> refers
to the maximum number of subjects per selected active arm.</dd>

</dl>