param_typeOfShape

The shape of the dose-response relationship over the treatment groups. 
This can be either <code>"linear"</code>, <code>"sigmoidEmax"</code>, or <code>"userDefined"</code>.
If <code>"sigmoidEmax"</code> is selected, <code>"gED50"</code> and <code>"slope"</code> has to be entered 
to specify the ED50 and the slope of the sigmoid Emax model.
For <code>"linear"</code> and <code>"sigmoidEmax"</code>, <code>"muMaxVector"</code> specifies the range 
of effect sizes for the treatment group with highest response. 
If <code>"userDefined"</code> is selected, <code>"effectMatrix"</code> has to be entered.

typeOfShape

Parameter Description: Type Of Shape

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

param_typeOfShape function

<dl><dt>typeOfShape</dt>
<dd>The shape of the dose-response relationship over the treatment groups. 
This can be either <code>"linear"</code>, <code>"sigmoidEmax"</code>, or <code>"userDefined"</code>.
If <code>"sigmoidEmax"</code> is selected, <code>"gED50"</code> and <code>"slope"</code> has to be entered 
to specify the ED50 and the slope of the sigmoid Emax model.
For <code>"linear"</code> and <code>"sigmoidEmax"</code>, <code>"muMaxVector"</code> specifies the range 
of effect sizes for the treatment group with highest response. 
If <code>"userDefined"</code> is selected, <code>"effectMatrix"</code> has to be entered.</dd></dl>

Arguments

Parameter Description: Type Of Shape — param_typeOfShape

<dl>

<dt>typeOfShape</dt>
<dd>The shape of the dose-response relationship over the treatment groups. 
This can be either <code>"linear"</code>, <code>"sigmoidEmax"</code>, or <code>"userDefined"</code>.
If <code>"sigmoidEmax"</code> is selected, <code>"gED50"</code> and <code>"slope"</code> has to be entered 
to specify the ED50 and the slope of the sigmoid Emax model.
For <code>"linear"</code> and <code>"sigmoidEmax"</code>, <code>"muMaxVector"</code> specifies the range 
of effect sizes for the treatment group with highest response. 
If <code>"userDefined"</code> is selected, <code>"effectMatrix"</code> has to be entered.</dd>

</dl>