ConditionalPowerResults

Class for conditional power calculations

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

ConditionalPowerResults function

<dl>
<dt><code>nPlanned</code></dt>
<dd>The new sample size planned for each of the subsequent stages.</dd></dl>
<dt><code>allocationRatioPlanned</code></dt>
<dd>The planned allocation ratio <code>n1/n2</code> for a
two treatment groups design, default is <code>1</code>. Is a numeric vector of length 1.</dd>
<dt><code>iterations</code></dt>
<dd>The number of iterations used for simulations. Is an integer of length 1.</dd>
<dt><code>seed</code></dt>
<dd>The seed used for random number generation. Is a numeric vector of length 1.</dd>
<dt><code>simulated</code></dt>
<dd>Logical. Describes if the power for Fisher's combination test
has been simulated. Only applicable when using Fisher designs.</dd>
<dt><code>conditionalPower</code></dt>
<dd>The conditional power at each stage of the trial.
Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>thetaH1</code></dt>
<dd>For survival designs, refers to the hazard ratio. Is a numeric vector of length 1.</dd>
<dt><code>assumedStDev</code></dt>
<dd>The assumed standard deviation. Is a numeric vector of length 1.</dd>

Fields

Conditional Power Results — ConditionalPowerResults

<dl>
<dt><code>nPlanned</code></dt>
<dd>The new sample size planned for each of the subsequent stages.</dd>


<dt><code>allocationRatioPlanned</code></dt>
<dd>The planned allocation ratio <code>n1/n2</code> for a
two treatment groups design, default is <code>1</code>. Is a numeric vector of length 1.</dd>


<dt><code>iterations</code></dt>
<dd>The number of iterations used for simulations. Is an integer of length 1.</dd>


<dt><code>seed</code></dt>
<dd>The seed used for random number generation. Is a numeric vector of length 1.</dd>


<dt><code>simulated</code></dt>
<dd>Logical. Describes if the power for Fisher's combination test
has been simulated. Only applicable when using Fisher designs.</dd>


<dt><code>conditionalPower</code></dt>
<dd>The conditional power at each stage of the trial.
Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>thetaH1</code></dt>
<dd>For survival designs, refers to the hazard ratio. Is a numeric vector of length 1.</dd>


<dt><code>assumedStDev</code></dt>
<dd>The assumed standard deviation. Is a numeric vector of length 1.</dd>


</dl>

ConditionalPowerResults: Conditional Power Results

Description

Arguments

Fields

Details