StageResultsRates

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

StageResultsRates function

<dl>
<dt><code>stages</code></dt>
<dd>The stage numbers of the trial. Is an integer vector of length <code>kMax</code>.</dd></dl>
<dt><code>testStatistics</code></dt>
<dd>The stage-wise test statistics. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>overallTestStatistics</code></dt>
<dd>The overall i.e. cumulated test statistics. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>pValues</code></dt>
<dd>The stage-wise p-values. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>overallPValues</code></dt>
<dd>The overall i.e. cumulated p-values. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>combInverseNormal</code></dt>
<dd>The stage-wise test statistics for the inverse normal test. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>combFisher</code></dt>
<dd>Test statistic for Fisher's combination test. H~0~</dd>
<dt><code>effectSizes</code></dt>
<dd>The stage-wise effect sizes. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>testActions</code></dt>
<dd>The action drawn from test result.</dd>
<dt><code>weightsFisher</code></dt>
<dd>The weights for Fisher's combination test. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>weightsFisher</code></dt>
<dd>The weights for inverse normal statistic.. Is a numeric vector of length <code>kMax</code>.</dd>
<dt><code>normalApproximation</code></dt>
<dd>Logical. Describes if a normal approximation was used when calculating p-values.
Default for means is <code>FALSE</code> and <code>TRUE</code> for rates and hazard ratio.</dd>

Fields

Stage Results of Rates — StageResultsRates

<dl>
<dt><code>stages</code></dt>
<dd>The stage numbers of the trial. Is an integer vector of length <code>kMax</code>.</dd>


<dt><code>testStatistics</code></dt>
<dd>The stage-wise test statistics. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>overallTestStatistics</code></dt>
<dd>The overall i.e. cumulated test statistics. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>pValues</code></dt>
<dd>The stage-wise p-values. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>overallPValues</code></dt>
<dd>The overall i.e. cumulated p-values. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>combInverseNormal</code></dt>
<dd>The stage-wise test statistics for the inverse normal test. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>combFisher</code></dt>
<dd>Test statistic for Fisher's combination test. H~0~</dd>


<dt><code>effectSizes</code></dt>
<dd>The stage-wise effect sizes. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>testActions</code></dt>
<dd>The action drawn from test result.</dd>


<dt><code>weightsFisher</code></dt>
<dd>The weights for Fisher's combination test. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>weightsFisher</code></dt>
<dd>The weights for inverse normal statistic.. Is a numeric vector of length <code>kMax</code>.</dd>


<dt><code>normalApproximation</code></dt>
<dd>Logical. Describes if a normal approximation was used when calculating p-values.
Default for means is <code>FALSE</code> and <code>TRUE</code> for rates and hazard ratio.</dd>


</dl>

StageResultsRates: Stage Results of Rates

Description

Arguments

Fields

Details