param_allocationRatioPlanned

Parameter Description: Allocation Ratio Planned

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Stephen Schueuerhuis

param_allocationRatioPlanned function

<dl><dt>allocationRatioPlanned</dt>
<dd>The planned allocation ratio <code>n1 / n2</code> for a two treatment groups
design, default is <code>1</code>. For multi-arm designs, it is the allocation ratio relating the active arm(s) to the control.
For simulating means and rates for a two treatment groups design, it can be a vector of length kMax, the number of stages.
It can be a vector of length kMax, too, for multi-arm and enrichment designs.
In these cases, a change of allocating subjects to treatment groups over the stages can be assessed.</dd></dl>

Arguments

Parameter Description: Allocation Ratio Planned — param_allocationRatioPlanned

<dl>

<dt>allocationRatioPlanned</dt>
<dd>The planned allocation ratio <code>n1 / n2</code> for a two treatment groups
design, default is <code>1</code>. For multi-arm designs, it is the allocation ratio relating the active arm(s) to the control.
For simulating means and rates for a two treatment groups design, it can be a vector of length kMax, the number of stages.
It can be a vector of length kMax, too, for multi-arm and enrichment designs.
In these cases, a change of allocating subjects to treatment groups over the stages can be assessed.</dd>

</dl>