param_directionUpper

Parameter Description: Direction Upper

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Stephen Schueuerhuis

param_directionUpper function

<dl><dt>directionUpper</dt>
<dd>Logical. Specifies the direction of the alternative,
only applicable for one-sided testing; default is <code>TRUE</code>
which means that larger values of the test statistics yield smaller p-values.</dd></dl>

Arguments

Parameter Description: Direction Upper — param_directionUpper

<dl>

<dt>directionUpper</dt>
<dd>Logical. Specifies the direction of the alternative,
only applicable for one-sided testing; default is <code>TRUE</code>
which means that larger values of the test statistics yield smaller p-values.</dd>

</dl>