param_allocationRatioPlanned_sampleSize

Parameter Description: Allocation Ratio Planned With Optimum Option

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Stephen Schueuerhuis

Tobias Muetze

param_allocationRatioPlanned_sampleSize function

<dl><dt>allocationRatioPlanned</dt>
<dd>The planned allocation ratio <code>n1 / n2</code> for a two treatment groups
design, default is <code>1</code>. If <code>allocationRatioPlanned = 0</code> is entered,
the optimal allocation ratio yielding the smallest overall sample size is determined.</dd></dl>

Arguments

Parameter Description: Allocation Ratio Planned With Optimum Option — param_allocationRatioPlanned_sampleSize

<dl>

<dt>allocationRatioPlanned</dt>
<dd>The planned allocation ratio <code>n1 / n2</code> for a two treatment groups
design, default is <code>1</code>. If <code>allocationRatioPlanned = 0</code> is entered,
the optimal allocation ratio yielding the smallest overall sample size is determined.</dd>

</dl>