param_typeOfComputation

Parameter Description: Type Of Computation

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Stephen Schueuerhuis

Tobias Muetze

param_typeOfComputation function

<dl><dt>typeOfComputation</dt>
<dd>Three options are available: <code>"Schoenfeld"</code>, <code>"Freedman"</code>, <code>"HsiehFreedman"</code>,
the default is <code>"Schoenfeld"</code>. For details, see Hsieh (Statistics in Medicine, 1992).
For non-inferiority testing (i.e., <code>thetaH0 != 1</code>), only Schoenfeld's formula can be used.</dd></dl>

Arguments

Parameter Description: Type Of Computation — param_typeOfComputation

<dl>

<dt>typeOfComputation</dt>
<dd>Three options are available: <code>"Schoenfeld"</code>, <code>"Freedman"</code>, <code>"HsiehFreedman"</code>,
the default is <code>"Schoenfeld"</code>. For details, see Hsieh (Statistics in Medicine, 1992).
For non-inferiority testing (i.e., <code>thetaH0 != 1</code>), only Schoenfeld's formula can be used.</dd>

</dl>