getLambdaStepFunction

Calculates the lambda step values for a given time vector.

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Daniel Sabanes Bove

Stephen Schueuerhuis

Tobias Muetze

getLambdaStepFunction function

<dl><dt>timeValues</dt>
<dd>A numeric vector that specifies the time values for which the lambda step values shall be calculated.</dd>
<dt>...</dt>
<dd>Ensures that all arguments (starting from the "...") are to be named and
that a warning will be displayed if unknown arguments are passed.</dd>
<dt>piecewiseSurvivalTime</dt>
<dd>A numeric vector that specifies the time intervals for the piecewise
definition of the exponential survival time cumulative distribution function (see details).</dd>
<dt>piecewiseLambda</dt>
<dd>A numeric vector that specifies the assumed hazard rate in the treatment group.</dd></dl>

Arguments

Get Lambda Step Function — getLambdaStepFunction

<dl>

<dt>timeValues</dt>
<dd>A numeric vector that specifies the time values for which the lambda step values shall be calculated.</dd>


<dt>...</dt>
<dd>Ensures that all arguments (starting from the "...") are to be named and
that a warning will be displayed if unknown arguments are passed.</dd>


<dt>piecewiseSurvivalTime</dt>
<dd>A numeric vector that specifies the time intervals for the piecewise
definition of the exponential survival time cumulative distribution function (see details).</dd>


<dt>piecewiseLambda</dt>
<dd>A numeric vector that specifies the assumed hazard rate in the treatment group.</dd>

</dl>

getLambdaStepFunction: Get Lambda Step Function

Description

Usage

Value

Arguments

Details