param_calcEventsFunction

Parameter Description: Calculate Events Function

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Daniel Sabanes Bove

Stephen Schueuerhuis

Tobias Muetze

param_calcEventsFunction function

<dl><dt>calcEventsFunction</dt>
<dd>Optionally, a function can be entered that defines the way of performing the sample size
recalculation. By default, event number recalculation is performed with conditional power and specified
<code>minNumberOfEventsPerStage</code> and <code>maxNumberOfEventsPerStage</code> (see details and examples).</dd></dl>

Arguments

Parameter Description: Calculate Events Function — param_calcEventsFunction

<dl>

<dt>calcEventsFunction</dt>
<dd>Optionally, a function can be entered that defines the way of performing the sample size
recalculation. By default, event number recalculation is performed with conditional power and specified
<code>minNumberOfEventsPerStage</code> and <code>maxNumberOfEventsPerStage</code> (see details and examples).</dd>

</dl>