param_selectPopulationsFunction

Parameter Description: Select Populations Function

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Daniel Sabanes Bove

Stephen Schueuerhuis

Tobias Muetze

param_selectPopulationsFunction function

<dl><dt>selectPopulationsFunction</dt>
<dd>Optionally, a function can be entered that defines the way of how populations
are selected. This function is allowed to depend on <code>effectVector</code> with length <code>populations</code>
<code>stage</code>, <code>conditionalPower</code>, <code>conditionalCriticalValue</code>, <code>plannedSubjects/plannedEvents</code>,
<code>allocationRatioPlanned</code>, <code>selectedPopulations</code>, <code>thetaH1</code> (for means and survival), <code>stDevH1</code> (for means),
<code>overallEffects</code>, and for rates additionally: <code>piTreatmentsH1</code>, <code>piControlH1</code>, <code>overallRates</code>, and
<code>overallRatesControl</code> (see examples).</dd></dl>

Arguments

Parameter Description: Select Populations Function — param_selectPopulationsFunction

<dl>

<dt>selectPopulationsFunction</dt>
<dd>Optionally, a function can be entered that defines the way of how populations
are selected. This function is allowed to depend on <code>effectVector</code> with length <code>populations</code>
<code>stage</code>, <code>conditionalPower</code>, <code>conditionalCriticalValue</code>, <code>plannedSubjects/plannedEvents</code>,
<code>allocationRatioPlanned</code>, <code>selectedPopulations</code>, <code>thetaH1</code> (for means and survival), <code>stDevH1</code> (for means),
<code>overallEffects</code>, and for rates additionally: <code>piTreatmentsH1</code>, <code>piControlH1</code>, <code>overallRates</code>, and
<code>overallRatesControl</code> (see examples).</dd>

</dl>