param_stDevSimulation

Parameter Description: Standard Deviation for Simulation

internal

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Friedrich Pahlke

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Gernot Wassmer

Till Jensen

Daniel Sabanes Bove

Stephen Schueuerhuis

Tobias Muetze

param_stDevSimulation function

<dl><dt>stDev</dt>
<dd>The standard deviation under which the data is simulated,
default is <code>1</code>.
For two-armed trials, it is allowed to specify the standard deviations separately,
i.e., as vector with two elements.
If <code>meanRatio = TRUE</code> is specified, <code>stDev</code> defines
the coefficient of variation <code>sigma / mu2</code>.</dd></dl>

Arguments

Parameter Description: Standard Deviation for Simulation — param_stDevSimulation

<dl>

<dt>stDev</dt>
<dd>The standard deviation under which the data is simulated,
default is <code>1</code>.
For two-armed trials, it is allowed to specify the standard deviations separately,
i.e., as vector with two elements.
If <code>meanRatio = TRUE</code> is specified, <code>stDev</code> defines
the coefficient of variation <code>sigma / mu2</code>.</dd>

</dl>