aging

A data frame of DNAm gestational age for both case and control groups.

dataset

Placental epigenetic clock to estimate aging based on gestational age using DNA methylation levels, so called placental epigenetic clock (PlEC). We developed a PlEC for the 2024 Placental Clock DREAM Challenge (<https://www.synapse.org/Synapse:syn59520082/wiki/628063>). Our PlEC achieved the top performance based on an independent test set. PlEC can be used to identify accelerated/decelerated aging of placenta for understanding placental dysfunction-related conditions, e.g., great obstetrical syndromes including preeclampsia, fetal growth restriction, preterm labor, preterm premature rupture of the membranes, late spontaneous abortion, and placental abruption. Detailed methodologies and examples are documented in our vignette, available at <https://herdiantrisufriyana.github.io/rplec/doc/placental_aging_analysis.html>.

Herdiantri Sufriyana

rplec

Placental Epigenetic Clock to Estimate Aging by DNA Methylation

Emily Chia-Yu Su

aging function

A data frame vector with 10 rows and 1 column:<dl>
<dt>output</dt>
<dd>A numeric value of residual DNAm gestational age (weeks).</dd>
</dl>

Format

Residual DNA-methylation-based (DNAm) gestational age — aging

A data frame vector with 10 rows and 1 column:<dl>
<dt>output</dt>
<dd>A numeric value of residual DNAm gestational age (weeks).</dd>


</dl>

aging: Residual DNA-methylation-based (DNAm) gestational age

Description

Usage

Arguments

Format