ruminate (version 0.3.1)

dose_records_builder: Builds Dose Records Dataframe

Description

Takes information about columns in dataset and constructs the dosing records.

Usage

dose_records_builder(
  NCA_DS = NULL,
  dose_from = NULL,
  col_id = NULL,
  col_time = NULL,
  col_ntime = NULL,
  col_route = NULL,
  col_dose = NULL,
  col_cycle = NULL,
  col_dur = NULL,
  col_evid = NULL,
  col_analyte = NULL,
  col_group = NULL
)

Value

list containing the following elements

• isgood: Return status of the function.

• msgs: Messages to be passed back to the user.

• dose_rec:

Arguments

NCA_DS

Dataset containing dosing records.

dose_from

Method of dose extraction either "cols" or "rows".

col_id

Name of column with subject ID.

col_time

Name of column with time since first dose.

col_ntime

Name of column with time since the last dose (required with dose_from="cols").

col_route

Name of column with route information.

col_dose

Name of column with last dose given.

col_cycle

Name of column with dose cycle (required with dose_from="cols").

col_dur

Name of column with dose duration.

col_evid

Name of column with event ID (required with dose_from="rows").

col_analyte

Name of column with analyte (optional).

col_group

Names of columns with grouping information (optionl).

Examples

if(system.file(package="readxl") !=""){
library(dplyr)
library(readxl)
library(stringr)

# Example data file:
data_file =  system.file(package="formods","test_data","TEST_DATA.xlsx")

# Dataset formatted to extract dosing from columns
DS_cols = readxl::read_excel(path=data_file, sheet="DATA")        |>
 dplyr::filter(EVID == 0)                                |>
 dplyr::filter(DOSE %in% c(3))                           |>
 dplyr::filter(str_detect(string=Cohort, "^MD"))         |>
 dplyr::filter(CMT == "C_ng_ml")

drb_res = dose_records_builder(
 NCA_DS     = DS_cols,
 dose_from  = "cols",
 col_id     = "ID",
 col_time   = "TIME_DY",
 col_ntime  = "NTIME_DY",
 col_route  = "ROUTE",
 col_cycle  = "DOSE_NUM",
 col_dose   = "DOSE",
 col_group  = "Cohort")

utils::head(drb_res$dose_rec)

# Dataset formatted to extract dosing from rows (records)
DS_rows = readxl::read_excel(path=data_file, sheet="DATA")        |>
 dplyr::filter(DOSE %in% c(3))                                   |>
 dplyr::filter(str_detect(string=Cohort, "^MD"))                 |>
 dplyr::filter(CMT %in% c("Ac", "C_ng_ml"))

drb_res = dose_records_builder(
 NCA_DS     = DS_rows,
 dose_from  = "rows",
 col_id     = "ID",
 col_time   = "TIME_DY",
 col_ntime  = "NTIME_DY",
 col_route  = "ROUTE",
 col_dose   = "AMT",
 col_evid   = "EVID",
 col_group  = "Cohort")

utils::head(drb_res$dose_rec)
}