getTgroup


Internal function where there are multiple shrinkage targets.


 ~kwd1 

 ~kwd2 

The purpose of this package is to discover the genes that
are differentially expressed between two conditions in RNA-seq
experiments. Gene expression is measured in counts of
transcripts and modeled with the Negative Binomial (NB)
distribution using a shrinkage approach for dispersion
estimation. The method of moment (MM) estimates for dispersion
are shrunk towards an estimated target, which minimizes the
average squared difference between the shrinkage estimates and
the initial estimates. The exact per-gene probability under the
NB model is calculated, and used to test the hypothesis that
the expected expression of a gene in two conditions identically
follow a NB distribution.

Danni Yu

sSeq

Shrinkage estimation of dispersion in Negative Binomial models
for RNA-seq experiments with small sample size

getTgroup function

Internal function where there are multiple shrinkage targets.

getTgroup: This is an internal function used to calculate the shrinkage estimation when multiple shrinkage targets are considered.

Description

Usage

Arguments

See Also

Examples