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samon (version 4.0.2)

Sensitivity Analysis for Missing Data

Description

In a clinical trial with repeated measures designs, outcomes are often taken from subjects at fixed time-points. The focus of the trial may be to compare the mean outcome in two or more groups at some pre-specified time after enrollment. In the presence of missing data auxiliary assumptions are necessary to perform such comparisons. One commonly employed assumption is the missing at random assumption (MAR). The 'samon' package allows the user to perform a (parameterized) sensitivity analysis of this assumption. In particular it can be used to examine the sensitivity of tests in the difference in outcomes to violations of the MAR assumption. The sensitivity analysis can be performed under two scenarios, a) where the data exhibit a monotone missing data pattern (see the samon() function), and, b) where in addition to a monotone missing data pattern the data exhibit intermittent missing values (see the samonIM() function).

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Version

Install

install.packages('samon')

Monthly Downloads

202

Version

4.0.2

License

GPL-2

Maintainer

Aidan McDermott

Last Published

October 26th, 2023

Functions in samon (4.0.2)

samonDifferenceSummaryIM

Summary function for the difference in treatment
samonevalIM

Evaluates the loss function at a range of smoothing parameters
samonTable1

Summarizes two treatment groups.
samonIM

samonIM: Sensitivity analysis for monotone missing and intermittent missing data
samoneval

Evaluates the loss function on a range of sigmas
The DepWork trial

The depression and working status trial.
samonCombine

Combines results from separate runs of the samon function
samonCombineIM

Combines results from separate runs of the samonIM function
samon

Sensitivity Analysis for monotone missing data
The PANSS trial.

The PANSS randomized trial.
samonCrossSummary

Summary function for the difference in effect of two treatments at different sensitivity parameters alpha.
alpha0TablesIM

Makes samonIM result tables at sensitivity parameter alpha=0.
alpha0Tables

Makes samon result tables at alpha = 0
The VAS trial.

The VAS randomized trial.
ManData

Data used in the man page examples.
samonCrossSummaryIM

Summary function for the difference in effect of two treatments at different sensitivity parameters.
samonSummary

Summary function for an object returned by the samon function
samonDifferenceSummary

Summary function for the difference in treatment effect
samonDataCheck

Samon Data Check
samonGenIM

Sensitivity Analysis for monotone missing data
samonSummaryIM

Summary function for an object returned by the samonIM function
samonECompleterStatus

Computes the difference in the expected value of non-completers and completers
samonGen

Sensitivity Analysis for monotone missing data